Najrelevantniji geni za nasljedne karcinome

GeneKarcinom dojkeKarcinom ovarijaKarcinom matericeKarcinom debelog crijevaMelanomKarcinom pankreasaKarcinom želucaKarcinom prostate*
* CDK4: analysis is limited to chr12:g.58145429-58145431 (codon 24). EPCAM: analysis is limited to deletions that minimally encompass the 3’ end of the gene including exons 8 and/or 9. GREM1: analysis is limited to duplications that overlap the upstream regulatory region. MITF: analysis is limited to chr3:g.70014091 (including c.952G>A). PMS2: variants of uncertain significance are not reported for exons 12-15. Analysis excludes three variants commonly observed in the pseudogene PMS2CL: c.2182_2184delinsG, c.2243_2246delAGAA and deletion of exons 13-14 (chr7:g.6015768_6018727del). POLD1: analysis is limited to chr19:g.50909713 (including c.1433G>A). POLE: analysis is limited to chr12:g.133250250 (including c.1270C>G).
BRCA1
BRCA2
MLH1
MSH2
MSH6
PMS2*
EPCAM*
APC
MUTYH
MITF*
BAP1
CDKN2A
CDK4*
TP53
PTEN
STK11
CDH1
BMPR1A
SMAD4
GREM1*
POLD1*
POLE*
PALB2
CHEK2
ATM
BARD1
BRIP1
RAD51C
RAD51D